๋ฆฌ๋ณด์†œ - Automated design of synthetic ribosome binding sites to control protein expression

๋ฆฌ๋ณด์†œ ๋™๋ฌผ์„ธํฌ

๋ฆฌ๋ณด์†œ ์‹๋ฌผ ์„ธํฌ์™€

๋ฆฌ๋ณด์†œ [์„ธํฌ์ƒ๋ฌผํ•™] ์„ธํฌ์†Œ๊ธฐ๊ด€์˜

๋ฆฌ๋ณด์†œ Ribosomal protein

๋ฆฌ๋ณด์†œ ๋™๋ฌผ์„ธํฌ

๋ฆฌ๋ณด์†œ Ribosomal protein

๋ฆฌ๋ณด์†œ์ด๋ž€...

๋ฆฌ๋ณด์†œ [์„ธํฌ์ƒ๋ฌผํ•™] ์„ธํฌ์†Œ๊ธฐ๊ด€์˜

๋ฆฌ๋ณด์†œ ๋™๋ฌผ์„ธํฌ

์‹๋ฌผ ์„ธํฌ์™€ ๋™๋ฌผ ์„ธํฌ์˜ ์ฐจ์ด์ 

๋ฆฌ๋ณด์†œ Ribosome

๋™๋ฌผ์„ธํฌ

๋ฆฌ๋ณด์†œ ๋ฆฌ๋ณด์†œ์ด๋ž€

์‹๋ฌผ ์„ธํฌ์™€ ๋™๋ฌผ ์„ธํฌ์˜ ์ฐจ์ด์ 

Ribosome

Shunqi Runโ€ข ๊ฐ๊ฐ์˜ ์•ฝ์ œ ํด๋ž˜์Šค ์ค‘์—์„œ 1๊ฐœ์”ฉ์„ ์„ ์ •ํ•˜๊ณ  , ์•„์ง€ํŠธ๋กœ๋งˆ์ด์‹  ,๋…์‹œ์‚ฌ์ดํด๋ฆฐ , ํƒ€์ด์ œ์‚ฌ์ดํด๋ฆฐ tigecycline , ํŒŒ๋ชจ์‚ฐํŒŒ์ด๋ฅด๋น„๋Š„ pyrvinium pamoate , ํด๋กœ๋žŒํŽ˜๋‹ˆ์ฝœ์˜ ๋ถ„์„ ๊ฒฐ๊ณผ๋ฅผ ๋ณด๊ณ ํ•œ๋‹ค.

  • ๋น„ํƒ€๋ฏผ C ๋Š” ์˜จํ™”ํ•œ ์‚ฐํ™”์ด‰์ง„์ œ๋กœ ์ž‘์šฉํ•˜๊ณ  , free radical์„ ์ƒ์„ฑํ•˜์—ฌ ๊ทธ ๊ฒฐ๊ณผ๋ฏธํ† ์ฝ˜๋“œ๋ฆฌ์•„ ์ƒํ•ฉ์„ฑ mitochondrial biogenesis ์„ ์œ ๋„ํ•œ๋‹ค.

๋ฆฌ๋ณด์†œ์ด๋ž€...

์ด๊ฒƒ์€ ์ž‘์€ ์ชฝ์˜ 40S ์„œ๋ธŒ์œ ๋‹›๊ณผ ๋” ํฐ ์ชฝ์˜ 60S ์„œ๋ธŒ์œ ๋‹›์œผ๋กœ ๊ตฌ์„ฑ๋˜์–ด ์žˆ์Šต๋‹ˆ๋‹ค.

  • Acad.

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